全麻，究竟会不会影响孩子的智力发育？

　　参考文献：

　　1. Raitts JA, Groenewald CB, Moriarty JP, Flick R. Epidemiology of amulatory anesthesia for children in the United States: 2006 and 1996. Anesth Analg 2010; 111:1011.

　　2. Tzong KY, Han S, Roh A, Ing C. Epidemiology of pediatric surgical admissions in US children: data from the HCUP kids inpatient dataase. J Neurosurg Anesthesiol 2012; 24:391.

　　3. Bjur KA, Payne ET, Nemergut ME, et al. Anesthetic-Related Neurotoxicity and Neuroimaging in Children: A Call for Conversation. J Child Neurol 2017; 32:594.

　　4. Jevtovic-Todorovic V, Hartman RE, Izumi Y, et al. Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat rain and persistent learning deficits. J Neurosci 2003; 23:876.

　　5. Istaphanous GK, Loepke AW. General anesthetics and the developing rain. Curr Opin Anaesthesiol 2009; 22:368.

　　6. r J, Alvarado MC, Murphy KL, Baxter MG. Multiple Anesthetic Exposure in Infant Monkeys Alters Emotional Reactivity to an Acute Stressor. Anesthesiology 2015; 123:1084.

　　7. Coleman K, Roertson ND, Dissen GA, et al. Isoflurane Anesthesia Has Long-term Consequences on Motor and Behavioral Development in Infant Rhesus Macaques. Anesthesiology 2017; 126:74.

　　8. McCann ME, de Graaff JC, Dorris L, etal. Neurodevelopmental outcome at 5 years of age after general anaesthesia orawake-regional anaesthesia in infancy (GAS): an international, mulre,randomised, controlled equivalence trial. Lancet. 2019 Fe16;393(10172):664-677.

　　9. FDA Drug Safety Communication: FDA review results in new warnings aout using general anesthetics and sedation drugs in young children and pregnant women. 2016.

　　10. s://www.fda.gov/Drugs/DrugSafety/ucm554634.htm.

　　11. ract Advisory: FDA warnings regarding use of general anesthetics and sedation drugs in young children and pregnant women. The American College of Ostetricians and Gynecologists. Decemer 21, 2016.

　　12. Consensus Statement on the Use of Anesthetic and Sedative Drugs in Infants and Toddlers. 2015.

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